Mouse Monoclonal Antibody to CD14(Clone :BS9)
Figure-1: Tonsil section have been stained using CD14 antibody (Clone: BS9) with 1:200 dilution. Follicular dendritic cells have strong label as well as macrophages in perifollicular area.
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| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1 |
| Content : | TRIS with 0.03% sodium azide, pH7.2 |
| Storage condition : | Store at 4°C |
CD14 antigen is a GPI-linked glycoprotein with a molecular weight of 55kD. The CD14 antigen is expressed on cells of the myelomonocytic lineage including monocytes, macrophages and Langerhans cells. Low expression is observed on neutrophils and on human B cells. CD14 antigen is a receptor for bacterial lipopolysaccharide (LPS, endotoxin) and the lipopolysaccharide binding protein (LBP). LBP and CD14 antigen serves two physiological roles. These proteins act as opsonin and opsonic receptor, respectively, to promote the phagocytic uptake of bacteria or LPScoated particles by macrophages.
Immunohistochemical Analysis :-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Secreted, Membrane raft, Golgi apparatus |
| Post transnational modification: | N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Tissue Specificity: | Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| BioGrid: | 107367. 35 interactions. |
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