Mouse Monoclonal Antibody to CASP3 (Clone: 1262CT521.280.101)(Discontinued)

Product code: 10-6603

Clone name : 1262CT521.280.101
Clonality : Monoclonal
Application : WB
Reactivity : Human

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Format : Purified
Amount : 400 µl
Isotype : Mouse IgG1
Purification : Protein G Chromatography
Content : Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Storage condition : Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene : CASP3
Gene ID : 836
Uniprot ID : P42574
Alternative Name : Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32
Immunogen Information : Recombinant Protein
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

WB~1:2000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
BioGrid: 107286. 102 interactions.
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