Mouse Monoclonal Antibody to CAMKK2 (Clone: 239CT7.5.3)(Discontinued)
Figure 1: Western blot analysis of CAMKK2 antibody (10-6556) in Jurkat cell line lysates (35μg/lane). This demonstrates the CAMKK2 antibody detected the CAMKK2 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgM,Kappa |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Gene : | CAMKK2 |
| Gene ID : | 10645 |
| Uniprot ID : | Q96RR4 |
| Alternative Name : | Calcium/calmodulin-dependent protein kinase kinase 2, CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, CAMKK2, CAMKKB, KIAA0787 |
| Immunogen Information : | Recombinant Protein |
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.
WB~1:100~250
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Cell projection |
| Post transnational modification: | Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. |
| Tissue Specificity: | Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. |
| BioGrid: | 115889. 30 interactions. |
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