Mouse Monoclonal Antibody to C-myc(Clone: 9 E10)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded Breast carcinoma stained with c-myc antibody ( 10-11518).
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| Format : | Ascites |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1 |
| Content : | This antibody is supplied as diluted ascites containing sodium azide as preservative. |
| Storage condition : | Store at 2-8°C. |
This antibody recognizes an epitope located in the amino acid residue 410-419 of human oncogene product c-myc. This antibody reacts with both components of the p62 and p64 c-myc.
IHC : 1:25-1:50
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Nucleus |
| Post transnational modification: | Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity). |
| BioGrid: | 110694. 668 interactions. |
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