Mouse Monoclonal Antibody to Beta-Actin (Clone: 137CT26.1.1)(Discontinued)

Product code: 10-6528

Clone name : 137CT26.1.1
Clonality : Monoclonal
Application : FACS, WB, IF
Reactivity : Rat, Mouse, Human

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Format : Purified
Amount : 400 µl
Isotype : Mouse IgG1,Kappa
Purification : Protein G Chromatography
Content : Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Storage condition : Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene : ACTB
Gene ID : 60
Uniprot ID : P60709
Alternative Name : Actin, cytoplasmic 1, Beta-actin, Actin, cytoplasmic 1, N-terminally processed, ACTB
Immunogen Information : Recombinant Protein

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.

FACS~1:25|| WB~1:1000|| IHC-P~1:10~50

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
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