Mouse Monoclonal Antibody to BCL6 (C-term)(Clone: 305CT16.3.3)(Discontinued)
Figure 1:Western blot analysis of BCL6 Antibody (10-6564) in NCI-H292 cell line lysates (35μg/lane). This demonstrates the BCL6 antibody detected the BCL6 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgG1,Kappa |
| Purification : | Protein G Chromatography |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This
protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced
transcript variants encoding different protein isoforms have been found for this gene.
WB~1:100~250
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Post transnational modification: | Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways. |
| Tissue Specificity: | Expressed in germinal center T- and B-cells and in primary immature dendritic cells. |
| BioGrid: | 107076. 119 interactions. |
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