Mouse Monoclonal Antibody to Bcl-2(Clone: 124)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded human tonsil stained with Bcl-2 Oncoprotein ( 10-11503).
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1, Kappa |
| Content : | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
| Storage condition : | Store at 2-8°C. |
This antibody recognizes a protein of 25-26kDa, identified as bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. This antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and small number in which neoplastic cells are bcl-2 negative.
IHC : 1:50-1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane |
| Post transnational modification: | Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome. |
| Tissue Specificity: | Expressed in a variety of tissues. |
| BioGrid: | 107068. 102 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
