Mouse Monoclonal Antibody to AKT3 (Clone: 154CT4.5.3)(Discontinued)
Figure 1: Western blot analysis of AKT3 antibody (10-6539) in mouse NIH-3T3 cell line lysates (15μg/lane). This demonstrates the AKT3 antibody detected the AKT3 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgG1,Lambda |
| Purification : | Protein G Chromatography |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).
WB~1:100~500|| IHC-P~1:50~100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Membrane |
| Post transnational modification: | O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1. |
| Tissue Specificity: | In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. |
| BioGrid: | 115318. 26 interactions. |
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