Mouse Monoclonal Antibody to AKT2 (Clone: 148CT5.4.1.4)(Discontinued)
Figure 1: Western blot analysis of AKT2 antibody (10-6538) in mouse brain tissue lysates (15μg/lane).This demonstrates the AKT2 antibody detected the AKT2 protein.
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| Format : | Purified |
| Amount : | 400 µl |
| Isotype : | Mouse IgG1 |
| Purification : | Protein G Chromatography |
| Content : | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Storage condition : | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles. |
AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
WB~1:100~500|| IHC-P~1:50~100|| IF~1:10~50
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Cell membrane, Early endosome |
| Post transnational modification: | O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1. |
| Tissue Specificity: | Expressed in all cell types so far analyzed. |
| BioGrid: | 106711. 68 interactions. |
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