Mouse Monoclonal Antibody to Actin, Sarcomeric (5C5)(Clone: 5C5)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded human skeletal muscle stained with Actin Sarcomeric antibody ( 10-11516).
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| Format : | Ascites |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgM |
| Content : | This antibody is supplied as diluted ascites containing sodium azide as preservative. |
| Storage condition : | Store at 2-8°C. |
Monoclonal anti-α-sarcomeric actin has been used as a marker for rhabdomyosarcoma. This antibody is specific to α-skeletal and α-cardiac muscle actins. It does not react with smooth muscle tissue.
IHC : 1:25-1:50
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148). |
| BioGrid: | 106573. 145 interactions. |
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