Mouse Monoclonal Antibody to Actin, alpha smoothe muscle(Clone: 1A4)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded human colon stained with Actin, α-Smooth Muscle antibody ( 10-11556).
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG2a, Kappa |
| Content : | This antibody is supplied as purified immunoglobulin containing sodium azide as preservative. |
| Storage condition : | Store at 2-8°C. |
This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes. This antibody does not cross-react with β and γ-cytoplasmic, α-sarcomeric and α-myocardial actin isoforms.
IHC: 1:50-1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148). |
| BioGrid: | 106574. 170 interactions. |
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