Mouse Macrophage Inflammatory Protein-3 alpha (CCL20)
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Amount : | 100 µg |
Purification : | Reducing and Non-Reducing SDS PAGE at >= 95% |
Content : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Sterile water at 0.1 mg/mL |
Storage condition : | Store at -20°C |
AA sequence : | ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM |
Predicted MW:Â Monomer, 8 kDa (70 aa)
Macrophage inflammatory protein-3 alpha (MIP-3 alpha), also called CCL20, is expressed in the liver, lungs, lymph nodes, and peripheral blood lymphocytes. Â MIP-3 alpha expression is strongly induced by inflammatory signals, and downregulated by the anti-inflammatory cytokine interleukin 10 (IL-10). Â MIP-3 alpha signals through the G protein-coupled receptor CCR6 to function as a chemoattractant to lymphocytes and dendritic cells.Â
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.  Â
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Secreted |
Tissue Specificity: | Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL17 producing helper T-cells (Th17). |
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