Mouse CCL12 / MCP-5 Recombinant Protein (His Tag)(Discontinued)

Product code: 37-1334

Reactivity : Mouse

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For estimated delivery dates, please contact us at [email protected]


Amount : 100 µg
Purification : > (58.5+36.0) % as determined by SDS-PAGE.
Content : Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Storage condition : Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA sequence : Gly23-Gly104
Alternative Name : CCL12 Protein, Mouse; MCP-5 Protein, Mouse; Scya12 Protein, Mouse
Source : Yeast
Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1alpha is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia.

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For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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