Mouse Anti-Human IL-33

Product code: 31-3775

Clone name : SB127c
Clonality : Monoclonal
Application : ELISA
Conjugate : Unconjugated

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0.5 mg
$572.00 

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Amount : 0.5 mg
Isotype : Mouse IgG2b
Content : 0.5 mg/ml, 1.0 ml, Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Storage condition : Store at 2-8°C
Gene : IL33
Gene ID : 90865
Uniprot ID : O95760
Alternative Name : IL33, C9orf26, IL1F11, NFHEV
Subcellular location: Nucleus, Chromosome, Cytoplasmic vesicle, Secreted
Post transnational modification: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.
Tissue Specificity: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
BioGrid: 124776. 7 interactions.
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