Mouse Anti-Human CD36-FITC (Clone: SMÏ•)
Figure 1: Human peripheral blood platelets were stained with Mouse Anti-Human CD36-FITC . Purple: CD36- FITC, Gray: FITC conjugated Isotype control.
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Shipping Info:
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| Amount : | 100 Tests |
| Isotype : | Mouse IgM, kappa |
| Content : | 1.0 ml, Supplied in PBS/Sodium azide |
| Storage condition : | Store at 2-8°C |
CD36, also known as GPIV, is an 88 kDa glycoprotein that is a receptor for extracellular matrix proteins such as collagen and thrombospondin. Its expression is restricted to platelets, monocytes, macrophages, erythrocyte precursors, adipocytes, activated keratinocytes, and some endothelial and epithelial cells. CD36 is a multifunctional protein that has roles as a cell adhesion molecule, a scavenger receptor, a signal transducer and in the pathogenesis of malaria via its affinity for Plasmodium falciparum erythrocyte membrane protein 1 (PEMP1). CD36 on macrophages functions in the phagocytic clearance of apoptotic cells.
| Subcellular location: | Cell membrane, Membrane raft, Golgi apparatus, Apical cell membrane |
| Post transnational modification: | Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783). |
| BioGrid: | 107386. 18 interactions. |
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