Monoclonal Antibody to Ubiquitin (Clone: Ubi-1)
Figure-1: Formalin fixed paraffin embedded section of cerebral cortex of an Alzheimer patient processed with 34-1119 using HRP/DAB, giving a brown signal. Also stained with haemotoxylin in blue. A typical flame shaped tangle is seen in a pyramidal neuron in the center and is surrounded by some dystrophic neurites, also strongly ubiquitin positive. Both are commonly seen in cortical and hippocampal Alzheimer brain sections and are typical for this disease, but are rare or absent in healthy brain.
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| Format : | Ascites |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG1 |
| Content : | Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody or ascites fluid. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
WB: 1:1,000-1:2,000. ICC/IF and IHC: 1:2,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Ubiquitin: Mono-ADP-riblosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones. |
| BioGrid: | 113162. 187 interactions. |
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