Monoclonal Antibody to TOX-3 (Clone: ABM44A1)
Fig-1: Western blot analysis of TOX-3. Anti- TOX-3 antibody (Clone: ABM44A1) was tested at 2 µg/ml on (1) PC3, (2) h Testis, (3) HCT-116, (4) h Lung, (5) h Brain, (6) MCF-7 and (7) U87 lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TOX high mobility group box family member 3 (TOX-3) is a member of a subfamily of transcription factors that contains a High Mobility Group box (HMG-box), involved in bending and unwinding of DNA and alteration of chromatin structure. It has two transcript variants encoding different isoforms.TOX3 is expressed in estrogen receptor-positive mammary epithelial cells, including progenitor cells and highly expressed in luminal B breast cancers. Its over expression in human oligodendrocytes reduced cellular death under conditions mimicking Spinal cord injury (SCI).
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Tissue Specificity: | Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe. |
| BioGrid: | 118139. 2 interactions. |
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