Monoclonal antibody to TLR7 (Clone: ABM2C27) FITC Conjugated
Fig:1- Intracellular flow analysis of TLR7-FITC conjugated in THP1 cells using 0.5 µg/10^6 cells of TLR7-FITC antibody (Clone: ABM2C27). Green represents isotype control; red represents anti- TLR7-FITC antibody.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.2 mg/ml in Tris buffer containing 0.05% Azide |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. |
TLR7 (Toll-like receptor 7) is a member of the Toll-like receptor (TLR) family. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA; which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 controls host immune response against pathogens through recognition of molecular patterns specific to microorganisims. TLR7 interacts with MYD88 via their respective TIR domains and also interacts with UNC93B1. Post-translational modifications and glycosylation occur in TLR7. TLR7 detected in brain, placenta, spleen, stomach, small intestine, lungs and plasmacytoid pre-dendritic cells.
FACS Analysis: 0.5-1 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle |
| Tissue Specificity: | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. |
| BioGrid: | 119436. 2 interactions. |
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