Monoclonal Antibody to TLR2 (Clone: ABM3A87) APC conjugated
Fig-1: Intracellular flow analysis of TLR2 APC conjugated in PBMC (Monocytes) using 0.5 µg/10^6 cells of TLR2 APC conjugated antibody (Clone: ABM3A87). Green represents isotype control; red represents anti-TLR2 APC conjugated antibody.
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| Format : | Purified |
| Amount : | 100 Test |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.04 mg/ml in PBS with 0.05% Azide. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
TLR2 (Toll-Like Receptors 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 also interacts with a large number of non-TLR molecules, allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial, and epithelial cells.
FACS analysis: 0.5 -1 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane, Cytoplasmic vesicle, Membrane raft |
| Post transnational modification: | Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. |
| Tissue Specificity: | Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. |
| BioGrid: | 112952. 27 interactions. |
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