Monoclonal Antibody to TLR10 (Clone: ABM3C85)
Fig-1: Western blot analysis of TLR10. Anti- TLR10 antibody (Clone: ABM3C85) was used at 2 µg/ml on human Ovary lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2a Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| Tissue Specificity: | Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines. |
| BioGrid: | 123585. 10 interactions. |
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