Monoclonal antibody to TIM-3 (Clone: ABM31A8)

Product code: 10-4076

Clone name : ABM31A8
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : HAVCR2
Gene ID : 84868
Uniprot ID : Q8TDQ0
Alternative Name : T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM3, TIMD3

FlowCytometry: 0.5-1 µg/10^6 Cells 

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
Tissue Specificity: Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
BioGrid: 124313. 72 interactions.
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