Monoclonal Antibody to TIA-1 (Clone: ABM47E1)
Fig-1: Immunohistochemical analysis of TIA-1 in human Liver carcinoma tissue using TIA-1 antibody (Clone: ABM47E1) at 5 µg/ml.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5' splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.
Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis: 5-10 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| BioGrid: | 112928. 43 interactions. |
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