Monoclonal Antibody to RIG-I (Clone: ABM4H29)

Product code: 10-4121

Clone name : ABM4H29
Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human

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Price

Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Tuesday November 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : DDX58
Gene ID : 23586
Uniprot ID : O95786
Alternative Name : DDX58
Immunogen Information : A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody.

RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5'-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS).

Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 15 µg/ml,  Flowcytometric analysis: 0.5-1µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cell projection, Cytoplasm, Cell junction
Post transnational modification: Sumoylated, probably by MUL1; inhibiting its polyubiquitination.
Tissue Specificity: Present in vascular smooth cells (at protein level).
BioGrid: 117121. 43 interactions.
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