Monoclonal Antibody to Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker)(Clone : 4F10)

Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Apical cell membrane, Cell projection, Cell projection, Cell projection, Cell projection, Membrane raft, Membrane
Post transnational modification:	N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
Tissue Specificity:	Glomerular epithelium cell (podocyte).
BioGrid:	111416. 22 interactions.

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