Monoclonal Antibody to Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker)(Clone : 4F10)

Product code: 36-1567

Clone name : 4F10
Clonality : Monoclonal
Application : FACS, IF, IHC
Reactivity : Human, Rat

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100 µg
$520.00 

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgM, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PODXL
Gene ID : 5420
Uniprot ID : O00592
Alternative Name : PODXL, PCLP, PCLP1
Immunogen Information : A recombinant protein fragment containing the intracellular, transmembrane, and part of the extracellular domain of human podocalyxin
Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Apical cell membrane, Cell projection, Cell projection, Cell projection, Cell projection, Membrane raft, Membrane
Post transnational modification: N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
Tissue Specificity: Glomerular epithelium cell (podocyte).
BioGrid: 111416. 22 interactions.
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