Monoclonal Antibody to p27Kip1 (Mitotic Inhibitor/Suppressor Protein)(Clone : DCS-72.F6)

Product code: 36-1011

Clone name : DCS-72.F6
Clonality : Monoclonal
Application : FACS, IF, WB, IHC
Reactivity : Human, Mouse, Rat

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100 µg
$520.00 

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, kappa
Purification : Affinity Chromatography
Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CDKN1B
Gene ID : 1027
Uniprot ID : P46527
Alternative Name : CDKN1B, KIP1
Immunogen Information : Mouse recombinant p27 protein
Recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. Its epitope spans between aa 83-204 of p27. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. This MAb co-precipitates cdk4 in complex p27Kip1 and is excellent for staining of formalin-fixed tissues.

Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Cytoplasm, Endosome
Post transnational modification: Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity).
Tissue Specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
BioGrid: 107461. 94 interactions.
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