Monoclonal Antibody to p105/p50 (Clone: ABM20H5)
Fig-1: Western blot analysis of p50. Anti-p50 antibody (Clone: ABM20H5) was tested at 1 µg/ml on THP1, Ramos, Jurkat and Raji lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
p50 (KBF1, p105, EBP-1, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. Activation of p50 regulates the expression of inflammatory genes crucially involved in the pathogenesis of inflammatory diseases. It governs the expression of adhesion molecules that play a pivotal role in leukocyte-endothelium interactions. p50 activation plays an essential role in the activation of mesangial cells and macrophages through the transcriptional induction of inflammatory mediators of glomerular inflammation and injury.
Western blot analysis: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm |
| Post transnational modification: | The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation. |
| BioGrid: | 110857. 192 interactions. |
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