Monoclonal antibody to Mouse TLR4 CD284 (Clone: MTS510) FITC Conjugated
Figure-1: Cell surface flow analysis of FITC conjugated mTLR4 antibody (cloneMTS510) in mSplenocytes using 0.5 µg/10^6 cells. Green represents isotype control; red represents FITC conjugated anti-mTLR4 antibody.
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Order now and get it on Tuesday November 19, 2024
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rat IgG2a, Kappa |
| Purification : | Protein G purification |
| Content : | 0.2 mg/ml in Tris buffer containing 0.05% Azide |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types.
FACS: 0.5-1 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Tissue Specificity: | Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Expressed in macrophages. |
| BioGrid: | 204224. 24 interactions. |
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