Monoclonal Antibody to Mouse PD-L1 (Clone: 10F.9G2)

Product code: 10-7648

Clone name : 10F.9G2
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Tuesday December 24, 2024

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Format : Purified
Amount : 100 µg
Isotype : Rat IgG2b, k
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : Cd274
Gene ID : 60533
Uniprot ID : Q9EP73
Alternative Name : Programmed cell death 1 ligand 1, Programmed cell death 1 ligand 1, Programmed death ligand 1, B7-H1
Immunogen Information : Mouse CD274

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1.  PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.

Flowcytometric Analysis: 0.2-0.4 µg/10^6 Cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Early endosome membrane, Recycling endosome membrane
Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Tissue Specificity: Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B-cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin.
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