Monoclonal Antibody to Mouse CD140b (PDGF Receptor b) NALE™ Purified (Clone: APB5)
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| Amount : | 100 µg |
| Isotype : | Rat IgG2a, kappa |
| Content : | 1 mg/ml in Phosphate-buffered aqueous solution, ph7.2. |
| Storage condition : | The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. |
The APB5 monoclonal antibody specifically binds to the mouse CD140b molecule, otherwise known as the Platelet-Derived Growth Factor (PDGF) Receptor beta chain. CD140b is a receptor tyrosine kinase expressed on embryonic tissue and adult mesenchymal-derived cells. The APB5 antibody is reported to block the binding of PDGF-BB to the PDGF receptor.
The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cytoplasmic vesicle, Lysosome lumen |
| Post transnational modification: | Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation. |
| Tissue Specificity: | Weakly expressed in glomerular mesangial cells and interstitial cells. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, increased expression in interstitial cells at day 4 and expression is markedly elevated at day 7 and is maximal at day 14. |
| BioGrid: | 202089. 5 interactions. |
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