Monoclonal Antibody to Mouse CD3 (Clone: 145-2C11)

Product code: 10-4123

Clone name : 145-2C11
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse

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  •   25 µg

  •  100 µg

  • $70.00 

  • $130.00 

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Shipping Info:

Order now and get it on Friday November 22, 2024

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Format : Purified
Amount : 100 µg
Isotype : Hamster IgG
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : Cd247
Gene ID : 12503
Uniprot ID : P24161
Alternative Name : T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247
Immunogen Information : Mouse BM10-37 cytotoxic T lymphocytes were used as immunogen for this antibody.

CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma delta TCR contains, and which support surface TCR expression and transduce the TCR signal. CD3D, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK).

FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Post transnational modification: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Tissue Specificity: CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs). Expressed also in retinal ganglion cells (PubMed:20188655).
BioGrid: 198598. 5 interactions.
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