Monoclonal Antibody to Mouse CD25 (Clone: PC61)
Figure-1: Cell Surface flow staining of mCD25 on Con-A treated mouse splenocytes using 0.5 µg/10^6 cells. Green represents isotype control; red represents anti-mouse CD25 antibody (10-4088, clone: PC61). Goat anti-rat FITC conjugated secondary antibody (ABEOMICS) was used.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rat IgG1 |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been shown to influence effector function of lymphocytes, it is thought to play a greater role in immune tolerance in mice. Constitutive expression of CD25 on Treg cells is thought to be crucial to their survival and maintenance of immune homeostasis. Expression of CD25 and its role in immunology may be species dependent, since CD25 appears to play a larger role in T-cell effector responses in humans compared to mice, and may be somewhat dispensable for the maintenance of Treg cells as seen in patients treated with CD25-blocking antibodies.
FACS: 0.5-1 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| BioGrid: | 109774. 4 interactions. |
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