Monoclonal Antibody to Mouse CD196 (Clone: ABM40H1)
Fig-1: Western blot analysis of mCD196. Anti-mCD196 antibody (Clone: ABM40H1) was used at 2 µg/ml on B16 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rat IgG2a, Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
CD196 displays a high degree of genetic homology between mouse and human. Moreover, in both species it is chromosomally segregated from the main chemokine receptor gene cluster. mCD196 is expressed by myeloid DCs (dendritic cells), mature B cells, subpopulations of memory/effector CD4+ and CD8+ T cells, but not plasmacytoid DCs or native T cells. mCD196 mediates their migration and function via stimulation with its ligand CCL20 (also known as macrophage inflammatory protein (MIP)-3alpha. mCD196 expression has been correlated with stage and prognosis in a variety of cancers including hepatocellular carcinoma, colorectal carcinoma, glioma, and non-small cell lung cancer. It is also believed to play a role in regulation of cancer progression.
WB: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell surface |
| Tissue Specificity: | Sperm. Mainly localized in the principal piece and neck region of the tail but is also found in the acrosomal region in a small percentage of sperm cells. Expressed in natural regulatory T cells (nTregs) and a subset of early thymocyte progenitor double-negative 1 (DN1) cells. Expressed in memory B cells. Expressed by IL17 producing helper T-cells (Th17), type 1 effector cells (Th1), type 2 effector cells (Th2) and regulatory T-cells (Treg) (at protein level). Expressed by Th17 cells in spleen, Peyers patches, and lamina propria of small and large intestine. Highly expressed in testis, lung, colon, and dendritic cells. |
| BioGrid: | 107640. 2 interactions. |
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