Monoclonal Antibody to IL-23R (Clone: ABM25G4)
Figure-1: : Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 µg/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
Western blot analysis: 1-2 µg/ml, Flowcytometric analysis: 2-4 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated in response to IL23. |
| Tissue Specificity: | Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. |
| BioGrid: | 127199. 3 interactions. |
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