Monoclonal Antibody to IDH1 (Clone: ABM44B3)

Product code: 10-7551

Clone name : ABM44B3
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Price

Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Thursday December 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2a Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : IDH1
Gene ID : 3417
Uniprot ID : O75874
Alternative Name : IDH1, PICD
Immunogen Information : A partial length recombinant IDH1 protein (amino acids 198-414) was used as the immunogen for this antibody
Isocitrate dehydrogenase 1 (IDH1) is a dimeric cytosolic NADP-dependent dehydrogenase that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate. It belongs to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). It serves a significant role in cytoplasmic NADPH production. It is found in the cytoplasm and peroxisomes. IDH1 is of great importance in cell metabolism and energy conversion. Mutations in IDH1 are found in a somatic mosaic fashion in patients with multiple enchondromas.

Immunohistochemical analysis: 5 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Peroxisome
Post transnational modification: Acetylation at Lys-374 dramatically reduces catalytic activity.
BioGrid: 109643. 62 interactions.
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