Monoclonal Antibody to human CTLA-4 (Clone:BN13)
Figure 1: Cell surface staining of PHA stimulated PBMC. Green represents isotope control. Red represents Anti-hCTLA-4 (10-7646). 0.5 ug antibody was used. Goat anti-mouse PE was used as secondary antibody.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2a, Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. |
| Tissue Specificity: | Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. |
| BioGrid: | 107875. 109 interactions. |
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