Monoclonal Antibody to Human CD40 NALE™ Purified (Clone: 5C3)

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Product code: 43-1004

Clone name :	5C3
Clonality :	Monoclonal
Application :	FACS
Reactivity :	Human

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Download TDS MSDS

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	500 µg
Isotype :	Mouse IgG1, kappa
Content :	1 mg/ml in Phosphate-buffered aqueous solution, ph7.2.
Storage condition :	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.


Gene :	CD40
Gene ID :	958
Uniprot ID :	P25942
Alternative Name :	B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5

The 5C3 monoclonal antibody specifically reacts with human CD40, a 48 kDa type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.

The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.