Monoclonal Antibody to Human CD3 NALE™ Purified (Clone: UCHT1)
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| Amount : | 500 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 2 mg/ml in Phosphate-buffered aqueous solution, ph7.2. |
| Storage condition : | The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein. |
The UCHT1 monoclonal antibody specifically reacts with the Epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains Gamma, Delta, and Epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3Epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| Post transnational modification: | Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. |
| Tissue Specificity: | CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs) (PubMed:11722641). |
| BioGrid: | 107357. 29 interactions. |
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