Monoclonal Antibody to Human CD14 NALE™ Purified (Clone: 61D3)
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 1 mg/ml in Phosphate-buffered aqueous solution, ph7.2. |
| Storage condition : | The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein. |
The 61D3 monclonal antibody specifically binds to human CD14, a co-receptor for bacterial lipopolysaccharides (LPS). It is expressed on some dendritic cells, monocytes and neutrophils. CD14 is involved in the body's innate immune response and cytokine expression in monocytes and neutrophils.
The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Secreted, Membrane raft, Golgi apparatus |
| Post transnational modification: | N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Tissue Specificity: | Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| BioGrid: | 107367. 35 interactions. |
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