Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54) PE Conjugated

Product code: 10-7562-P

Clone name : ABM4E54
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 Test
$290.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 Test
Isotype : Mouse IgG2a Kappa
Purification : Protein G Chromatography
Content : 25 Test in 125 µl/100 Test in 500 µl PBS containing 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months.
Gene : CD274
Gene ID : 29126
Uniprot ID : Q9NZQ7
Alternative Name : CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Immunogen Information : A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitates apoptosis of activated T cells, and induces T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.

FACS: 1-2 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endomembrane system
Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
BioGrid: 118891. 48 interactions.
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