Monoclonal Antibody to Human CD98 (Clone: ABM5A27)
Fig-1: Western blot analysis of hCD98. Anti-hCD98 antibody (Clone: ABM5A27) was used at 4 µg/ml on human Kidney lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | SLC3A2 |
| Gene ID : | 6520 |
| Uniprot ID : | P08195 |
| Alternative Name : | 4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, Solute carrier family 3 member 2 |
| Immunogen Information : | A partial length recombinant protein (a.a 162-371) of hCD98 was used as the immunogen for this antibody. |
CD98 was originally identified as a cell surface antigen associated with lymphocyte activation defined by 4F2 mAb; it is expressed in proliferating normal tissues and in almost all tumor cells. CD98 heterodimer consists of a type II single-pass transmembrane heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1; encoded by the genes SLC3A2 and Slc3a2 for human and mouse, respectively) of ~80–85 kDa that is disulfide-linked with a multi-pass light chain of ~40 kDa. CD98 hc (heavy chain) is a type II transmembrane glycoprotein that is disulfide-linked to a non-glycosylated light chain of a member of the permease family. It has been reported that CD98 was functionally involved in lymphocyte activation, cell proliferation, and malignant transformation. CD98 forms the large neutral amino acid transporter that is a heterodimeric membrane transport protein to transport branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. Intestinal epithelial cells express CD98 under the physiological conditions. Recent reports indicate that CD98 is involved in the intestinal inflammation, which can be upregulated by interferon (IFN)-gamma in the intestine.
WB: 4-6 µg/ml, FACS: 1-2 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Apical cell membrane, Melanosome |
| Post transnational modification: | Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. |
| Tissue Specificity: | Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. |
| BioGrid: | 112411. 98 interactions. |
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