Monoclonal Antibody to Human CD33 (Clone: wm53)

Product code: 10-4138

Clone name : wm53
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $75.00 

  • $130.00 

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Shipping Info:

Order now and get it on Tuesday November 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CD33
Gene ID : 945
Uniprot ID : P20138
Alternative Name : Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67
Immunogen Information : Human AML cells were used as immunogen for this antibody.

CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.

FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
Tissue Specificity: Monocytic/myeloid lineage cells.
BioGrid: 107383. 12 interactions.
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