Monoclonal antibody to Human CD25 (Clone: 7G7B6 ) APC Conjugated

Product code: 10-4125-AC

Clone name : 7G7B6
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : APC

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100 test
$130.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 test
Isotype : Mouse IgG2a Kappa
Purification : Protein G Chromatography
Content : 0.04mg/ml in PBS containing 0.05% Azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months.
Gene : IL2RA
Gene ID : 3559
Uniprot ID : P01589
Alternative Name : IL2RA, CD25
Immunogen Information : Recombinant human CD25 protein was used as an imunogen for this antidody.

CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been shown to influence effector function of lymphocytes, it is thought to play a greater role in immune tolerance in mice. Constitutive expression of CD25 on Treg cells is thought to be crucial to their survival and maintenance of immune homeostasis. Expression of CD25 and its role in immunology may be species dependent, since CD25 appears to play a larger role in T-cell effector responses in humans compared to mice, and may be somewhat dispensable for the maintenance of Treg cells as seen in patients treated with CD25-blocking antibodies.

FACS Analysis: 0.2-0.5 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
BioGrid: 109774. 4 interactions.
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