Monoclonal Antibody to Estrogen Receptor (Clone: C-71)(Discontinued)
Fig: 1 Intracellular staining of the human breast cancer line MCF7 using Estrogen Receptor antibody (Clone: C-71) at 1µg/10^6 cells.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
The estrogen receptor (ER) is a ~ 67kDa protein. The estrogen receptor gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. normal ER function. Many investigators have reported on the isolation of cDNAs which encode variant ER sequences.
Immunohistochemical analysis: 1:25-100; Flowcytometry analysis: 0.5-2 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Golgi apparatus, Cell membrane |
| Post transnational modification: | Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor. |
| Tissue Specificity: | Widely expressed. Isoform 3 is not expressed in the pituitary gland. |
| BioGrid: | 108403. 738 interactions. |
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