Monoclonal Antibody to EpCAM (Clone: VU-1D9)
Figure-1:Surface staining of HT29 cells using EpCAM antibody (red) and isotype control antibody (green) at 0.2 µg/10^6 cells (Clone: VU-1D9).
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | EPCAM |
| Gene ID : | 4072 |
| Uniprot ID : | P16422 |
| Alternative Name : | EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1 |
| Immunogen Information : | The NC1-H69 human small cell lung carcinoma line was used as immunogen to generate the EpCAM antibody. The antibody binding epitope has been mapped to the first EGF-like repeat domain (EGF1) amino acids 27-59 of the EpCAM protein. |
EpCAM (epithelial specific antigen) is an ~40 kDa transmembrane glycoprotein involved in a number of cellular processes including adhesion, proliferation, maintenance of stemness, migration and invasion. EpCAM is expressed on most, but not all, normal epithelia and their corresponding malignancies. Although the role of EpCAM expression in tumorigenesis remains to be fully elucidated, EpCAM may downregulate immunity and help tumors actively escape from immune surveillance.
Immunohistochemical analysis: 1:100-1:200; Flowcytometry analysis: 0.2-0.5 µg/10^6 cells, Western blot analysis: 4-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Lateral cell membrane, Cell junction |
| Post transnational modification: | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
| BioGrid: | 110250. 5 interactions. |
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