Monoclonal Antibody to DNMT3a (Clone: ABM1F35) FITC Conjugated

Product code: 10-7004-F

Clone name : ABM1F35
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

Shipping Info:

Order now and get it on Tuesday December 24, 2024

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price
100 µg
$290.00 

Add to Wish List

Shipping Info:

Order now and get it on Tuesday December 24, 2024

Same day delivery FREE on San Diego area orders placed by 1.00 PM


Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1 Kappa
Purification : Protein G Chromatography
Content : 25 µg in 125 µl/100 µg in 500 µl Tris and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months.
Gene : DNMT3A
Gene ID : 1788
Uniprot ID : Q9Y6K1
Alternative Name : DNMT3A
Immunogen Information : Full length recombinant DNMT3a protein was used as the immunogen for this antibody

Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).

FACS: 0.5-2 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Cytoplasm
Post transnational modification: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
BioGrid: 108125. 53 interactions.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products