Monoclonal Antibody to DDX3 (Clone: ABM27H2)
Fig-1: Western blot analysis of DDX3. Anti- DDX3 antibody (Clone: ABM27H2) was used at 2 µg/ml on (1) MCF-7,(2) NIH3T3 (3) HEK293 and (4) EL-4 lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
DDX3 (DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked) is having a large family of ATP-dependent RNA helicases that involve in several steps of RNA metabolism. Main functions of DDX3 involve transcription, mRNA export and translation, regulation of apoptosis and hepatitis C virus (HCV) replication. DDX3 has two isoforms produced by alternative splicing. The cytoplasmic form is highly phosphorylated in the G1/S. DDX3 is primarily expressed in nucleus during G0 phase and in the cytoplasm during G1/S phase.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus speckle, Cytoplasm, Mitochondrion outer membrane |
| Post transnational modification: | Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFNB induction. Phosphorylated by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3. The cytoplasmic form is highly phosphorylated in the G1/S phase and much lower phosphorylated in G2/M. |
| BioGrid: | 108020. 163 interactions. |
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