Monoclonal Antibody to Dc-Sign/CD 209 (Clone: ABM47B7)

Fig-1: Expression analysis of Dc-Sign. Anti-Dc-Sign antibody (Clone: ABM47B7) was tested at 0.1 µg/ml on partial length recombinant protein.

Monoclonal Antibody to Dc-Sign/CD 209 (Clone: ABM47B7)

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Fig-1: Expression analysis of Dc-Sign. Anti-Dc-Sign antibody (Clone: ABM47B7) was tested at 0.1 µg/ml on partial length recombinant protein.

Fig-2: Expression analysis of Dc-Sign. Anti-Dc-Sign antibody (Clone: ABM47B7) was tested at 0.1 µg/ml on human Liver lysate.

Fig-3: Cell Surface FLOW analysis of Dc-Sign antibody (10-10020) in 293HEK-Dc-sign stable cell line using 0.5 µg/ 10^6 cells. Green represents isotype control, red represents anti- Dc-Sign antibody. Goat anti-mouse PE conjugates was used as secondary antibody.

Product code: 10-10020

Clone name :	ABM47B7
Clonality :	Monoclonal
Application :	FACS, WB
Reactivity :	Human

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Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG2b Kappa
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	CD209
Gene ID :	30835
Uniprot ID :	Q9NNX6
Alternative Name :	CD209, CLEC4L
Immunogen Information :	A recombinant protein fragment of DC-Sign protein was used as the immunogen for this antibody.

Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery.

Western blot analysis: 0.1-0.5 µg/ml; FACS: 0.5-1 µg/10^6 Cells

Reference for expression of Dc-Sign:

Wai K. Lai, Phoebe J. Sun, Jie Zhang, Adam Jennings, Patricia F. Lalor, Stefan Hubscher,Jane A. McKeating,and David H. Adams. Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium Am J Pathol. 2006 Jul; 169(1): 200–208.doi: 10.2353/ajpath.2006.051191

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Tissue Specificity:	Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
BioGrid:	119051. 14 interactions.