Monoclonal Antibody to Cyclin D1 (G1-Cyclin & Mantle Cell Marker)(Clone : SPM587)-PE
Flow Cytometry of human Cyclin D1 on Jurkat Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled Cyclin D1 Monoclonal Antibody (SPM587).
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG2a, kappa |
| Purification : | Affinity Chromatography |
| Content : | PE conjugated Cyclin D1 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. |
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood); Immunofluorescence (1:50-1:100);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Membrane |
| Post transnational modification: | Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. |
| BioGrid: | 107067. 101 interactions. |
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