Monoclonal Antibody to Cyclin D1 (G1-Cyclin & Mantle Cell Marker)(Clone : CCND1/809)-PE

Product code: 36-1638

Clone name : CCND1/809
Clonality : Monoclonal
Application : FACS, IF
Reactivity : Human
Conjugate : PE

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0.5 ml
$520.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG2a, kappa
Purification : Affinity Chromatography
Content : PE conjugated CYclin D1 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Storage condition : Store the antibody at 4°C; stable for 6 months.
Gene : CCND1
Gene ID : 595
Uniprot ID : P24385
Alternative Name : CCND1, BCL1, PRAD1
Immunogen Information : Recombinant full-length human CCND1 protein

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);Immunofluorescence (1:50-1:100 for 30 minutes at RT);

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Cytoplasm, Membrane
Post transnational modification: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
BioGrid: 107067. 101 interactions.
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