Monoclonal Antibody to CK19 (Clone: A53-B/A2)

Product code: 10-7506

Clone name : A53-B/A2
Clonality : Monoclonal
Application : IHC, WB
Reactivity : Human

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100 µg
$290.00 

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Shipping Info:

Order now and get it on Tuesday November 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2a Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : KRT19
Gene ID : 3880
Uniprot ID : P08727
Alternative Name : KRT19
Immunogen Information : Human breast cancer MCF-7 cells were used as the immunogen for the Keratin-19 antibody.

Keratin-19 (K19) is a type I intermediate filament protein and one of the best characterized of the keratins expressed in mature striated muscle. Keratin-19 is expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium. Keratin-19 has been used as a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer. Immunohistochemical data has shown that Keratin-19 may be uses as a marker for human skin stem cells.

Western blot analysis: 0.01-3 µg/ml; Immunohistochemical analysis: 1:100-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Tissue Specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
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